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No significant change in Disease Activity Score 28-joint assessment (DAS28) was seen in any of the cohorts.

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Systemic clearance of mavrilimumab approached that of endogenous Ig G at doses 1.0 mg/kg; pharmacodynamic activity was confirmed in the 1.0 and 3.0 mg/kg cohorts by suppression of suppressor of cytokine signalling 3 m RNA transcripts.

In exploratory analyses, reductions of acute phase reactants were observed in subjects with elevated C-reactive protein (5 mg/l) and erythrocyte sedimentation rate (≥20.0 mm/h) at baseline.

In addition, the session focused on how to address the influence and conflict challenges that frequently arise when working toward full ABCDEF Bundle implementation.